解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The effect of neonatal hyperthyroidism produced by injection of tri-iodothyronine (T3) on myelination and on the microperoxisomal population of the brain was studied in young rats. Data on the lipid composition of myelin show that myelinogenesis starts earlier in treated animals. In coincidence with the early appearan...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250312
更新日期:1990-03-01 00:00:00
abstract::A rodent model of Parkinson's disease, the 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine treated mouse, was used to determine whether striatal dopamine levels recover following grafting adrenal medulla into the striatum. Four types of grafts were performed: 1) adult mouse adrenal medulla, 2) adult adrenal me...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250303
更新日期:1990-03-01 00:00:00
abstract::The expression of gangliosides of the lactosylceramide (LC) and of the gangliotetraosylceramide (GTC) series on the surface of cells from rat embryonic cerebellar tissue was investigated by double-color indirect immunofluorescence. GD3 was assumed to be representative of LC and was detected using a specific monoclonal...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250209
更新日期:1990-02-01 00:00:00
abstract::The ability of altered environmental conditions to modulate some properties of synaptosomes has been studied. Incubation conditions used included the presence of methyl mercury or an organochlorine insecticide: chlordecone. Other adverse chemical conditions during incubation were the absence of calcium salts from the ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250211
更新日期:1990-02-01 00:00:00
abstract::The mammalian genome contains both constitutively expressed and heat-shock-inducible members of the hsp70 gene family. Riboprobes derived from members of these two classes of heat shock genes were utilized in Northern blot studies to analyze brain mRNA isolated from control rabbits and rats and from animals subjected ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250103
更新日期:1990-01-01 00:00:00
abstract::Cultures of rat C6 rat glioma cells exhibit a diminished response to isoproterenol and forskolin after being treated with phorbol 12,13-dibutyrate (PDbU). An IC50 for PDbU of 38 +/- 5 nM and 62 +/- 8 nM was observed in the isoproterenol and forskolin response, respectively. Similarly, C6 cultures exhibited a diminishe...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250110
更新日期:1990-01-01 00:00:00
abstract::Immature and mature rat astroglia in culture were assayed for glutamine synthetase (GS) activity after a single exposure to the epileptogen FeCl2. Cells were cultured with both standard and elevated extracellular potassium or glutamate (Glu) concentrations. FeCl2 reduced GS activity below control levels, whereas high ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490240408
更新日期:1989-12-01 00:00:00
abstract::Glutamine synthetase (GS) activity was used as a marker to examine differences in astrocyte development in mice selectively bred for ethanol sensitivity: long sleep (LS), short sleep (SS), mild ethanol withdrawal (MEW), severe ethanol withdrawal (SEW) and control ethanol withdrawal (CEW). We found that 1) GS activity ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490240308
更新日期:1989-11-01 00:00:00
abstract::The incubation of murine thymocytes for 24 hr in the presence of cholinergic agonists induces selective proliferation of PNA- cells as measured by thymidine incorporation. The response of PNA- cells is mediated by the activation of nicotinic receptors. This conclusion is suggested by the inability of the muscarinic ag...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490240305
更新日期:1989-11-01 00:00:00
abstract::Metabolic fate of [8-14C]adenosine was studied in primary cultures of either astrocytes or neurons from the mouse brain. In astrocytes the main metabolic route was the formation of nucleotides. Thus, synthesis of adenosine triphosphate (ATP) amounted to about 0.2 nmol X min-1 X mg-1 protein. The deamination occurred l...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490240218
更新日期:1989-10-01 00:00:00
abstract::High levels of the proto-oncogene product, pp60c-src, have been found in developing and adult neural tissues as well as in certain fully mature cells of the hematopoietic lineage, e.g., platelets and myelomonocytes. Adrenal medullary chromaffin cells exhibit characteristics of both types of cells, i.e., they are deriv...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490240107
更新日期:1989-09-01 00:00:00
abstract::Cathepsin D-like activity in homogenates of five brain areas of 3-month-old and 24-month-old Fischer 344 rats was measured. With hemoglobin as substrate at pH 3.2, more than 90% of the activity was inhibited by pepstatin. In each area studied, activity was more than twice as high in the old rat brain: 140-160% higher ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490230412
更新日期:1989-08-01 00:00:00
abstract::HEPES inhibited the taurine uptake in glial cells. A different kind of inhibition was observed when HEPES was present in the culture medium or in the incubation medium used for the taurine-uptake measurement. As an example of a possible interference of HEPES in pharmacological experiments, we have studied the effect o...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490230111
更新日期:1989-05-01 00:00:00
abstract::Dissociated neurons from the neural tube containing the trigeminal motor nucleus from early chick embryos were cultured on laminin or collagen-polyornithine substrates, with and without nerve growth factor (NGF). Control cultures were grown in similar conditions with cytochrome-C. It was found that neuronal survival w...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220404
更新日期:1989-04-01 00:00:00
abstract::Culturing sympathetic ganglion neurons in vitro may modify phenotypic expression of some neurotransmitters. For dorsal root ganglia (DRG), contradictory results have been reported; most studies have used immature material. We have therefore performed a detailed immunocytochemical analysis of the transmitter content of...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220414
更新日期:1989-04-01 00:00:00
abstract::Scatchard analysis of saturation isotherms of [125I]-iodopindolol was used to characterize beta-adrenoceptor density (Bmax) and affinity constant (Kd) in female and male hamster Harderian glands. Single-point experiments were also completed in intact females, intact males, and castrated or superior cervical ganglionec...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220411
更新日期:1989-04-01 00:00:00
abstract::Brain slices obtained from young rats were incubated with different radioactive precursors, in the presence and absence of L-cycloserine (an inhibitor of the synthesis of sphingosine) in order to explore the possibility that transport of proteolipids--and specifically of the major myelin proteolipid PLP--to the myelin...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220309
更新日期:1989-03-01 00:00:00
abstract::Cultured astrocytes from neonatal rat cerebral hemispheres are depolarized by the excitatory neurotransmitter glutamate. In this study we have used selective agonists of different neuronal glutamate receptor subtypes, namely, the N-methyl-D-aspartate (NMDA), kainate, and quisqualate type, to characterize pharmacologic...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220307
更新日期:1989-03-01 00:00:00
abstract::The cerebral neocortex is known to modulate asymmetrically certain components of the immune system. It was previously shown that large ablation of the left cortex reduces B and T cell-mediated responses, whereas symmetrical right lesions enhance these responses. We have studied the immunomodulatory role of the brain c...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220212
更新日期:1989-02-01 00:00:00
abstract::Monoclonal antibody J1-31 (MAb J1-31, isotype IgG 2b) was raised against crude homogenate of brain tissue from a multiple sclerosis (MS) patient (autopsy sample; Malhotra et al.: Microbios Letters 26:151-157, 1984). In human brain, MAb J1-31 recognizes an intracellular protein antigen (J1-31 antigen), which bands at a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220106
更新日期:1989-01-01 00:00:00
abstract::Synaptic circuitry in the upper dorsal horn, disorganized due to transganglionic degenerative atrophy (evoked by blockade of retrograde axoplasmic transport in the related peripheral nerve), begins to be reestablished by a process of regenerative synaptoneogenesis as soon as retrograde transport is resumed. Central ax...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220110
更新日期:1989-01-01 00:00:00
abstract::The aim of the present study was to prepare cultures enriched in type-2 astrocytes (AS) and to analyze some of the properties of these cells over relatively long culture periods. Cultures enriched in type-2 AS were obtained by subculturing, at low cell density and in the presence of fetal calf serum, a cell population...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210211
更新日期:1988-10-01 00:00:00
abstract::In the embryonic and postnatal rat retina a cell surface antigen that is detected by monoclonal antibody JONES is distributed in a dorsoventral gradient. Biochemical analysis has determined that the antigen is a modified ganglioside, 9-O-acetyl GD3. In the present study, the distributions of 9-O-acetyl GD3 and its pos...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210231
更新日期:1988-10-01 00:00:00
abstract::To promote neurite elongation, nerve growth cones must adhere to other surfaces. A complex of integral membrane glycoproteins mediates cell binding to the extracellular glycoproteins fibronectin and laminin (Horwitz et al., J Cell Biol 101:2134-2144, 1985). The receptor complex, named integrin, binds to fibronectin by...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210221
更新日期:1988-10-01 00:00:00
abstract::The engrailed gene has been identified in Drosophila as an important developmental gene involved in the control of segmentation. Here we describe the embryonic expression of a chicken gene, ChickEn (Darnell et al.: J Cell Biol 103(5):311a, 1986), which contains homology to the Drosophila engrailed gene. Northern blots...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210234
更新日期:1988-10-01 00:00:00
abstract::The transfer of the adenovirus 5 E1A gene into brain cells from rat embryos led to the establishment of phenotypically untransformed clonal glial cell lines. Some lines displayed properties of oligodendrocyte-astrocyte progenitors. Their differentiation involved several steps that were dependent on culture conditions ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210112
更新日期:1988-09-01 00:00:00
abstract::The changes in ganglioside composition and metabolism of deafferentiated rat hippocampus were estimated after septal lesion. A significant decrease in total ganglioside concentration was found 7 days after the lesion. The reduced level of total gangliosides persisted at 17 and 25 days. Relative increase in the proport...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210107
更新日期:1988-09-01 00:00:00
abstract::The distribution of phosphofructokinase (PFK) in gray and white matter regions of the rat nervous system was evaluated. Determinations of PFK activity revealed that cell body enriched regions (sensorimotor cortex) had a significantly higher level of activity than axonal regions (sciatic nerve, dorsal roots, and optic ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210105
更新日期:1988-09-01 00:00:00
abstract::Ten days after bilateral injections of ibotenic acid into the nucleus basalis, rats injected daily (i.m.) with ganglioside GM1 were protected from anterograde degeneration of cholinergic projections to the fronto-lateral cortex. This protection was reflected by reduced losses (associated with ibotenic acid lesions) of...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200411
更新日期:1988-08-01 00:00:00
abstract::Primary cultures of cerebral glia derived from neonatal rat brain were utilized to determine 1) the developmental changes of dolichol-linked oligosaccharide and N-linked glycoprotein biosyntheses, 2) the enzymatic correlates of these developmental changes, and 3) the temporal relations between the biosyntheses of doli...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200409
更新日期:1988-08-01 00:00:00
abstract::Recent studies suggest that heterotypic cell-cell interactions influence gliogenesis in the developing rat central nervous system. CNS neuron-derived factors have been hypothesized to exist, and several have been identified and partially characterized which affect the number of oligodendrocytes in vitro. In order to s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200303
更新日期:1988-07-01 00:00:00
abstract::We have developed a silicone nerve regeneration chamber that is partitioned into two compartments by a strip of nitrocellulose paper. The modified two-compartment chamber allows the investigation of the effects on rat sciatic nerve regeneration of trophic or growth factors that are initially bound to the nitrocellulos...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200306
更新日期:1988-07-01 00:00:00
abstract::The effect of two different potassium channel blockers, 4-aminopyridine (4-AP) and quinine, on the alpha 2-adrenoceptor mediated modulation of norepinephrine (NE) release was investigated. Pairs of mouse vasa deferentia were loaded with 3H-norepinephrine (3H-NE), superfused continuously, and stimulated electrically. 4...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200114
更新日期:1988-05-01 00:00:00
abstract::Cultured purified oligodendroglia and astroglia exposed to heat stress (45 degrees C, 10 or 20 min) synthesized a 68-kDa heat-stress protein, which migrates on two-dimensional gel electrophoresis and reacts with a specific monoclonal antibody suggesting it is similar to a major 72-kDa heat-shock protein previously rep...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200103
更新日期:1988-05-01 00:00:00
abstract::The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490190311
更新日期:1988-03-01 00:00:00
abstract::Two clones encoding human glial fibrillary acidic protein (GFAP) were isolated from a human astrocytoma cDNA library. The clones pHGFAP1 and pHGFAP2 were selected by the combined use of differential colony hybridization and hybridization-selection technique with polyclonal anti GFAP antiserum. The longer one, pHGFAP1,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200204
更新日期:1988-01-01 00:00:00
abstract::Six different types of spectral responses were recorded from horizontal cells under mesopic conditions in perfused retina, isolated from the dark-adapted mojarra (Eugerres plumieri). They were tentatively termed photopic Lr-, Lg1-, Lg2-, Lb-, and C-type, and scotopic L-type. The Lr-, Lg-, and Lb-type responses showed ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200214
更新日期:1988-01-01 00:00:00
abstract::This study examined the growth of basal plate explants from 40-hr chick embryos containing the trigeminal motor nucleus in the presence of target muscle-conditioned medium (MCM) from day-4, day-10, and day-18 embryos. We had previously found that MCM derived from the 4-day target tissue enhanced neurite outgrowth from...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490190109
更新日期:1988-01-01 00:00:00
abstract::Seventeen white patients from the Stanford Sleep Disorders Clinic complaining of excessive daytime somnolence (EDS) were selected for restriction-fragment-length polymorphism (RFLP) studies. Fourteen of the patients with clinically diagnosed narcolepsy were seropositive for DR2. RFLP analysis of these patients compare...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180134
更新日期:1987-01-01 00:00:00
abstract::Nerve growth factor (NGF) is the best-characterized neurotrophic substance and has recently been shown to influence cholinergic neurons in the basal forebrain. Hippocampus and neocortex, the primary targets for these central neurons, have further been found to contain high levels of NGF. Using enzyme immunoassay and a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180404
更新日期:1987-01-01 00:00:00